Endocrine Abstracts

Prevention of familial diabetes mellitus is a most urgent problem in diabetology. Genetic susceptibility is a leading factor in diabetes mellitus onset.Aim: The work was initiated to assess potentiality of diabetes mellitus risk prediction based on genealogical analysis.Materials and methods: For the purpose of the study, 53 patients with diabetes mellitus were examined. The probands’ mean age was 14.4 years. Genealogical medi...

The work was initiated to study some biochemical parameters in peripheral blood of animals upon diet-induced obesity and insulin resistance modeling. Obesity was induced in BALB/c mice by keeping them on the high- carbon diet for 13 weeks. The commercially available kits were used to assay glucose, alkaline phosphatase, creatine kinase and cholesterol; concentrations of testosterone were measured by the enzyme immunoassay. The high carbon diet in BALB/c mice served as a basis ...

Diabetes mellitus (DM) is a most significant medical-social worldwide problem. Absence of reliable screening program for identification of persons with the higher risk of DM dictates a necessity of sensitive tests of early DM diagnosis. Following genealogical analysis, two experimental groups were formed; patients with type 1 DM with the familial burden (probands) and those at risk (siblings) were included into the 1st and 2nd groups, respectively. Apparently healthy subjects ...